As a very simple explanation, Moebius syndrome is a form of facial paralysis combined with outward, to the side, eye paralysis. Individuals with Moebius syndrome typically cannot make facial expressions, such as smiling, frowning, squinting, or blinking. Speech, eating, and lip movement may also be affected. People with Moebius syndrome also cannot move their eyes out to the side, as you would if you were looking over your shoulder without turning your head. The syndrome has a wide range of presentations and may occur on one or both sides of the face.